Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8560897 | 1.00 | ALDH1A1 (0.40) | ALDH1A1KDM4EMAPTHSD17B10HPGD | |
| Bromide SCHEMBL8560291 | 0.81 | KMT2A (0.45) | KDM4EMEN1KMT2ASIGMAR1LMNA | |
| Bromide SCHEMBL8898107 | 0.81 | KMT2A (0.45) | KDM4EMEN1KMT2ASIGMAR1LMNA | |
| Bromide SCHEMBL8897674 | 0.79 | ATM (0.51) | ALDH1A1KDM4EMAPTHSD17B10PKM | |
| Bromide SCHEMBL8565603 | 0.79 | ATM (0.51) | ALDH1A1KDM4EMAPTHSD17B10PKM | |
| Bromide SCHEMBL7880298 | 0.79 | MEN1 (0.43) | MEN1KMT2APOLB | |
| Bromide SCHEMBL7880295 | 0.79 | MEN1 (0.43) | MEN1KMT2APOLB | |
| Bromide SCHEMBL8567151 | 0.79 | NOTUM (0.35) | ALDH1A1KDM4EHSD17B10MEN1KMT2A | |
| Bromide SCHEMBL8899375 | 0.79 | NOTUM (0.35) | ALDH1A1KDM4EHSD17B10MEN1KMT2A | |
| Bromide SCHEMBL8567118 | 0.76 | SLC6A2 (0.47) | ALDH1A1MAPTHPGDHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5804577-A | ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1998-09-08 | — | — | US | disclosed |