Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | FPR1 | P21462 | 2/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.30 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8899375 | 1.00 | NOTUM (0.35) | NOTUMFPR2KMT2AMEN1KDM4E | |
| Bromide SCHEMBL8898107 | 0.89 | KMT2A (0.45) | NOTUMFPR2KMT2AMEN1KDM4E | |
| Bromide SCHEMBL8560291 | 0.89 | KMT2A (0.45) | NOTUMFPR2KMT2AMEN1KDM4E | |
| Bromide SCHEMBL8560903 | 0.79 | ALDH1A1 (0.40) | KMT2AMEN1KDM4ELMNAALDH1A1 | |
| Bromide SCHEMBL8560897 | 0.79 | ALDH1A1 (0.40) | KMT2AMEN1KDM4ELMNAALDH1A1 | |
| Bromide SCHEMBL8897674 | 0.76 | ATM (0.51) | KMT2AMEN1KDM4EALDH1A1MAPK1 | |
| Bromide SCHEMBL8565603 | 0.76 | ATM (0.51) | KMT2AMEN1KDM4EALDH1A1MAPK1 | |
| Bromide SCHEMBL7880298 | 0.76 | MEN1 (0.43) | FPR2KMT2AMEN1FPR1 | |
| Bromide SCHEMBL7880295 | 0.76 | MEN1 (0.43) | FPR2KMT2AMEN1FPR1 | |
| Bromide SCHEMBL8565406 | 0.75 | FADS1 (0.39) | LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5804577-A | ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1998-09-08 | — | — | US | disclosed |
| EP-0761673-A1 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-12 | — | — | EP | disclosed |