Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.45 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.45 |
| ▸ | FASN | P49327 | 1/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562060 | 0.82 | HTT (0.58) | HMGCRALDH1A1HPGDLTB4RLTB4R2 | |
| SCHEMBL8565876 | 0.81 | LTB4R (0.43) | LTB4RLTB4R2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18909755 | 0.75 | HMGCR (0.45) | HMGCRFASNNPC1RAB9ALMNA | |
| SCHEMBL22840673 | 0.74 | HPGD (0.68) | HMGCRALOX15HSD17B10ALDH1A1HPGD | |
| SCHEMBL8567276 | 0.74 | SLC6A4 (0.45) | ALDH1A1HPGDTUBB4ATUBBTUBA3C | |
| SCHEMBL25742812 | 0.73 | HSD17B10 (0.59) | ALOX15HSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL8567309 | 0.72 | FYN (0.43) | ALOX15TDP1LTB4RLTB4R2TUBB4A | |
| SCHEMBL11994151 | 0.72 | SLC6A4 (0.58) | HPGDLTB4R2TUBB4ATUBBTUBA3C | |
| SCHEMBL16488700 | 0.72 | HMGCR (0.54) | HMGCRALOX15HSD17B10ALDH1A1HPGD | |
| SCHEMBL19602918 | 0.70 | MAPT (0.75) | HMGCRALOX15HSD17B10ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544488-B1 | Substituted phenyl phenol leukotriene antagonists | LILLY CO ELI (US) | 1998-03-11 | — | — | EP | disclosed |
| WO-1996036347-A1 | USE OF LEUKOTRIENE ANTAGONISTS FOR ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1996-11-21 | — | — | WO | disclosed |
| EP-0743064-A1 | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease | ELI LILLY AND COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |
| US-5462954-A | Antiinflammatory, antiallergens; treating asthma | ELI LILLY AND COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0544488-A2 | Substituted phenyl phenol leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |