Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 9/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 9/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BCL9 | O00512 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562239 | 0.86 | SMN1; SMN2 (0.45) | LTB4RLTB4R2FFAR4NPC1RAB9A | |
| SCHEMBL8561282 | 0.81 | HMGCR (0.52) | LTB4RLTB4R2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8567880 | 0.77 | LTB4R (0.46) | LTB4RLTB4R2 | |
| SCHEMBL8565315 | 0.76 | L3MBTL1 (0.41) | LTB4RLTB4R2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15126033 | 0.75 | LTB4R (0.49) | LTB4RLTB4R2 | |
| SCHEMBL18909755 | 0.72 | HMGCR (0.45) | FFAR4NPC1RAB9ASMN1; SMN2CTNNB1 | |
| SCHEMBL8562241 | 0.72 | SYK (0.44) | FFAR4BCL9CTNNB1 | |
| SCHEMBL20795540 | 0.72 | HDAC8 (0.45) | FFAR4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8560925 | 0.71 | LTB4R (0.51) | LTB4RLTB4R2 | |
| SCHEMBL8567276 | 0.71 | SLC6A4 (0.45) | FFAR4NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544488-B1 | Substituted phenyl phenol leukotriene antagonists | LILLY CO ELI (US) | 1998-03-11 | — | — | EP | disclosed |
| WO-1996036347-A1 | USE OF LEUKOTRIENE ANTAGONISTS FOR ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1996-11-21 | — | — | WO | disclosed |
| EP-0743064-A1 | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease | ELI LILLY AND COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |
| US-5462954-A | Antiinflammatory, antiallergens; treating asthma | ELI LILLY AND COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0544488-A2 | Substituted phenyl phenol leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |