Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | NNMT | P40261 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562929 | 0.81 | CA1 (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGMAPK1 | |
| SCHEMBL15173500 | 0.71 | TDP1 (0.35) | PIK3CDPIK3CAPIK3CBPIK3CGMAP4K4 | |
| SCHEMBL31257580 | 0.71 | TDP1 (0.35) | PIK3CDPIK3CAPIK3CBPIK3CGMAP4K4 | |
| SCHEMBL9267446 | 0.70 | MAP4K4 (0.43) | MAP4K4LMNAMAPK1TP53MEN1 | |
| SCHEMBL12584018 | 0.69 | MAPKAPK2 (0.43) | MAP4K4HDAC1 | |
| SCHEMBL26765951 | 0.68 | GABRP (0.38) | SIRT6LMNAMAPK1NPC1NNMT | |
| SCHEMBL25350075 | 0.67 | KAT2B (0.37) | GAA | |
| SCHEMBL15173363 | 0.67 | KDM4E (0.40) | LMNANPC1GAAALDH1A1 | |
| SCHEMBL15740683 | 0.67 | LATS1 (0.33) | LMNA | |
| SCHEMBL17362420 | 0.66 | SIRT6 (0.47) | SIRT6LMNANNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |