Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562559 | 0.81 | CYP1A2 (0.55) | EPHX1TSHRSMN1; SMN2CYP1A2NAMPT | |
| SCHEMBL3430736 | 0.80 | EPHX1 (0.79) | EPHX1SMN1; SMN2CYP1A2NAMPTUSP2 | |
| SCHEMBL29881595 | 0.80 | EPHX1 (0.79) | EPHX1SMN1; SMN2CYP1A2NAMPTUSP2 | |
| SCHEMBL7605675 | 0.79 | HTT (0.72) | TSHRL3MBTL1SMN1; SMN2NAMPTALDH1A1 | |
| SCHEMBL3768797 | 0.79 | CYP11B2 (0.61) | TSHRL3MBTL1SMN1; SMN2NAMPTGAA | |
| SCHEMBL1161997 | 0.79 | NAMPT (0.75) | NAMPTGAAALDH1A1USP2LMNA | |
| SCHEMBL1928843 | 0.78 | SMN1; SMN2 (0.65) | EPHX1L3MBTL1SMN1; SMN2CYP1A2NAMPT | |
| SCHEMBL6962290 | 0.77 | CYP1A2 (0.65) | SMN1; SMN2CYP1A2LMNAHTTNPC1 | |
| SCHEMBL5334343 | 0.77 | MMP13 (0.79) | TSHRL3MBTL1SMN1; SMN2CYP1A2GAA | |
| SCHEMBL241619 | 0.76 | NPC1 (0.63) | L3MBTL1SMN1; SMN2CYP1A2NAMPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0596406-B1 | Imidazo (1,2-a) Pyridines as bradykinin antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-12-16 | — | — | EP | disclosed |
| US-5750699-A | HALOGENATING OF CORRESPONDING COMPOUND | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-12 | — | — | US | disclosed |
| US-5574042-A | ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN | FUJISAWA PHARMACEUTICAL CO., LTD (JP) | 1996-11-12 | — | — | US | disclosed |
| EP-0596406-A1 | Imidazo (1,2-a) Pyridines as bradykinin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-05-11 | — | — | EP | disclosed |