SCHEMBL8561762

SCHEMBL8561762

N#Cc1c([N+](=O)[O-])cc2ccccc2c1C#N

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CASP6 P55212 1/20 0.54
CYP3A4 P08684 1/20 0.53
TSHR P16473 2/20 0.51
TDP1 Q9NUW8 2/20 0.51
ALDH1A1 P00352 4/20 0.49
HPRT1 P00492 1/20 0.46
MAPT P10636 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
TLR9 Q9NR96 1/20 0.43
CDK2 P24941 1/20 0.42
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
HPGD P15428 1/20 0.40
CTSB P07858 2/20 0.39
VCAM1 P19320 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7638771 0.81 ALDH1A1 (0.55) CASP6CYP3A4TSHRTDP1ALDH1A1
SCHEMBL8561764 0.78 CYP3A4 (0.59) CASP6CYP3A4TSHRTDP1ALDH1A1
SCHEMBL188171 0.75 CYP3A4 (0.71) CASP6CYP3A4TSHRTDP1ALDH1A1
SCHEMBL8622947 0.74 HPRT1 (0.76) CASP6CYP3A4TSHRTDP1ALDH1A1
SCHEMBL29391266 0.73 ALDH1A1 (0.58) CYP3A4TSHRTDP1ALDH1A1MAPT
SCHEMBL32211 0.73 ALDH1A1 (0.58) CYP3A4TSHRTDP1ALDH1A1MAPT
SCHEMBL3607822 0.72 CTSB (0.59) CASP6TSHRTDP1ALDH1A1HPRT1
SCHEMBL28660711 0.72 HPRT1 (0.66) CASP6CYP3A4TSHRTDP1ALDH1A1
SCHEMBL31549326 0.71 CASP6 (0.59) CASP6CYP3A4TSHRTDP1ALDH1A1
SCHEMBL11203665 0.71 CASP6 (0.59) CASP6CYP3A4TSHRTDP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5763601-A SOLUBILITY, PURITY Shirai, Hirofusa (JP) 1998-06-09 US claimed
US-5763601-A SOLUBILITY, PURITY Shirai, Hirofusa (JP) 1998-06-09 US disclosed
US-5633370-A Naphthalocyanine compounds, naphthalocyanine polymers and method for making Shirai, Hirofusa (JP) 1997-05-27 US disclosed