Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.36 |
| ▸ | GSR | P00390 | 1/20 | 0.46 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.35 |
| ▸ | DPP4 | P27487 | 4/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL20678166 | 0.95 | GSR (0.50) | GSRPTGS1SLC7A11CPB2DPP7 | |
| Lysine SCHEMBL5575951 | 0.94 | GSR (0.51) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL29069496 | 0.94 | GSR (0.51) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL1675274 | 0.94 | GSR (0.51) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL28352738 | 0.92 | GSR (0.43) | GSRPTGS1SLC7A11CPB2DPP7 | |
| Lysine SCHEMBL28868906 | 0.92 | GSR (0.43) | GSRPTGS1SLC7A11CPB2DPP7 | |
| Lysine SCHEMBL18263286 | 0.91 | GSR (0.48) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL18259132 | 0.91 | GSR (0.48) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL17728306 | 0.90 | GSR (0.47) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL23834597 | 0.89 | GSR (0.57) | GSRDPP7DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756066-A | Iodine-containing peptides | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-05-26 | — | — | US | disclosed |
| EP-0835259-A1 | IODINE-CONTAINING PEPTIDES AND THEIR USE AS X-RAY CONTRAST MEDIA | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-04-15 | — | — | EP | disclosed |
| WO-1996040760-A2 | IODINE-CONTAINING PEPTIDES AND THEIR USE AS X-RAY CONTRAST MEDIA | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-12-19 | — | — | WO | disclosed |