Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PLTP | P55058 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556719 | 0.80 | GRM5 (0.44) | ALDH1A1HSD17B10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8558581 | 0.80 | KMT2A (0.49) | TRPV4ALDH1A1HSD17B10CYP1A2CYP2C9 | |
| SCHEMBL8557444 | 0.78 | MEN1 (0.65) | ALDH1A1CYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL8561965 | 0.77 | NPC1 (0.52) | TRPV4ALDH1A1HSD17B10CYP1A2CYP2C9 | |
| SCHEMBL8560930 | 0.76 | KMT2A (0.41) | TRPV4ALDH1A1HSD17B10CYP1A2CYP2C9 | |
| SCHEMBL8556724 | 0.72 | ALDH1A1 (0.42) | TRPV4ALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL9125033 | 0.70 | TRPV4 (0.41) | TRPV4ALDH1A1HSD17B10CYP1A2CYP2C9 | |
| SCHEMBL8557539 | 0.70 | TRPV4 (0.46) | TRPV4ALDH1A1HSD17B10CYP1A2CYP2C9 | |
| SCHEMBL8558406 | 0.68 | GAA (0.43) | ALDH1A1HSD17B10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8558589 | 0.67 | MEN1 (0.46) | TRPV4ALDH1A1HSD17B10MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518731-B1 | 2-(Indol-2-yl-carbonylamino)-thiazole derivatives, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-08-26 | — | — | EP | disclosed |
| US-5380736-A | Cholecystokinin and gastric antagonist | ELF SANOFI (FR) | 1995-01-10 | — | — | US | disclosed |
| US-5314889-A | Hormone antagonists | ELF SANOFI (FR) | 1994-05-24 | — | — | US | disclosed |
| EP-0518731-A1 | Heterocyclic derivatives of substituted 2-acylamino 5-thiazole, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-12-16 | — | — | EP | disclosed |