Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 14/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560556 | 0.93 | TACR1 (0.44) | TACR1 | |
| SCHEMBL8561651 | 0.91 | TACR1 (0.42) | TACR1GHSR | |
| SCHEMBL8562325 | 0.90 | MME (0.39) | TACR1GHSR | |
| SCHEMBL8559389 | 0.89 | TACR1 (0.42) | TACR1GHSR | |
| SCHEMBL8562658 | 0.89 | TACR1 (0.47) | TACR1 | |
| SCHEMBL8564275 | 0.88 | CTSS (0.49) | TACR1GHSR | |
| SCHEMBL8564711 | 0.88 | TACR1 (0.43) | TACR1GHSR | |
| SCHEMBL8559555 | 0.87 | TACR1 (0.40) | TACR1GHSR | |
| SCHEMBL8563536 | 0.87 | TACR1 (0.45) | TACR1GHSR | |
| SCHEMBL8560379 | 0.87 | CTSL (0.40) | TACR1GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811431-A | Spiro-substituted azacyclic derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 1998-09-22 | — | — | US | disclosed |
| EP-0775140-A1 | SPIRO-SUBSTITUTED AZACYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005203-A1 | SPIRO-SUBSTITUTED AZACYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1996-02-22 | — | — | WO | disclosed |