Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 7/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7084244 | 1.00 | EPHX2 (0.53) | EPHX2PTGS2AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL2534850 | 0.85 | CES2 (0.48) | — | |
| SCHEMBL6025710 | 0.85 | MAOA (0.56) | PTGS2CYP2C19PTGS1 | |
| SCHEMBL7836035 | 0.84 | PTGS2 (0.49) | PTGS2AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL7221221 | 0.84 | PTGS2 (0.49) | PTGS2AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL7505910 | 0.83 | EPHX2 (0.54) | EPHX2PTGS2AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL7507298 | 0.83 | EPHX2 (0.54) | EPHX2PTGS2AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL6184286 | 0.83 | EPHX2 (0.54) | EPHX2PTGS2AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL7220475 | 0.82 | AKR1C3 (0.51) | PTGS2AKR1C3PTGS1 | |
| SCHEMBL4585985 | 0.81 | EPHX2 (0.52) | EPHX2PTGS2AKR1C2AKR1C1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819127-A1 | IMIDAZO [1,2-a]PYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031509-A1 | IMIDAZO[1,2-a]PYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1996-10-10 | — | — | WO | disclosed |