Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 14/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8800666 | 0.82 | ACHE (0.51) | ACHEEPHX1ALDH1A1 | |
| SCHEMBL1534985 | 0.82 | ACHE (0.53) | ACHEEPHX1ALDH1A1 | |
| SCHEMBL28231754 | 0.80 | ACHE (0.50) | ACHEEPHX1ALDH1A1NPC1RAB9A | |
| SCHEMBL8909168 | 0.79 | ACHE (0.53) | ACHEEPHX1ALDH1A1NPC1RAB9A | |
| SCHEMBL3956624 | 0.79 | ACHE (0.53) | ACHEEPHX1ALDH1A1 | |
| SCHEMBL15775056 | 0.78 | ACHE (0.60) | ACHEEPHX1ALDH1A1 | |
| SCHEMBL970930 | 0.78 | ACHE (0.64) | ACHEEPHX1ALDH1A1 | |
| SCHEMBL28230804 | 0.78 | ACHE (0.47) | ACHEEPHX1ALDH1A1NPC1RAB9A | |
| SCHEMBL7048610 | 0.77 | ACHE (0.50) | ACHEEPHX1ALDH1A1 | |
| SCHEMBL13037023 | 0.76 | KDM4E (0.40) | EPHX1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432760-A1 | BRIDGED SPIRO [2.4]HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010134014-A1 | BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-11-25 | — | — | WO | disclosed |