Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | IGF1R | P08069 | 3/20 | 0.43 |
| ▸ | FLT4 | P35916 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 2/20 | 0.42 |
| ▸ | HTR1B | P28222 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7662475 | 0.91 | EGFR (0.49) | MAPKAPK2EGFRIGF1RFLT4KDR | |
| SCHEMBL7666158 | 0.88 | MAPKAPK2 (0.59) | MAPKAPK2ADRA1AEGFRIGF1RFLT4 | |
| SCHEMBL28074607 | 0.82 | EGFR (0.50) | MAPKAPK2EGFRIGF1RFLT4KDR | |
| SCHEMBL8562201 | 0.81 | MAPKAPK2 (0.53) | MAPKAPK2ADRA1AEGFRIGF1RFLT4 | |
| SCHEMBL28495179 | 0.81 | GABRA1 (0.52) | MAPKAPK2EGFRIGF1RFLT4KDR | |
| SCHEMBL11682262 | 0.80 | MAPKAPK2 (0.59) | MAPKAPK2ADRA1AEGFRIGF1RFLT4 | |
| SCHEMBL11842906 | 0.80 | MAPKAPK2 (0.54) | MAPKAPK2ADRA1AEGFRIGF1RFLT4 | |
| SCHEMBL28074399 | 0.79 | HDAC6 (0.49) | EGFRIGF1RFLT4KDRAKR1C3 | |
| SCHEMBL8757765 | 0.79 | MAPKAPK2 (0.60) | MAPKAPK2ADRA1APDE3BPDE3AKDM4E | |
| SCHEMBL28074596 | 0.78 | AKR1C3 (0.54) | EGFRIGF1RFLT4KDRAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998006402-A1 | TREATMENT OF THE COMMON COLD OR ALLERGIC RHINITIS | ELI LILLY AND COMPANY (US) | 1998-02-19 | — | — | WO | disclosed |
| US-5708187-A | MIGRANE HEADACHES | ELI LILLY AND COMPANY (US) | 1998-01-13 | — | — | US | disclosed |