Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 3/20 | 0.46 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | OXTR | P30559 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559885 | 0.93 | AVPR2 (0.46) | AVPR2AVPR1AKCNK3KCNK9AURKA | |
| SCHEMBL8559861 | 0.90 | AURKA (0.47) | AVPR2AVPR1AAURKAAURKB | |
| SCHEMBL8557883 | 0.87 | MEN1 (0.50) | AVPR2AVPR1ALMNATP53 | |
| SCHEMBL8562616 | 0.87 | ITGB1 (0.40) | AVPR2AVPR1ATP53 | |
| SCHEMBL8558194 | 0.86 | AKT1 (0.52) | AURKALMNATP53 | |
| SCHEMBL8556562 | 0.86 | KCNK3 (0.44) | AVPR2AVPR1AKCNK3KCNK9RXFP1 | |
| SCHEMBL8559901 | 0.85 | AVPR2 (0.63) | AVPR2AVPR1AOXTR | |
| SCHEMBL8560617 | 0.85 | AVPR1A (0.49) | AVPR2AVPR1ALMNA | |
| SCHEMBL8557851 | 0.84 | MAPT (0.48) | AVPR2AVPR1AAURKALMNATP53 | |
| SCHEMBL8557390 | 0.83 | AVPR2 (0.52) | AVPR2AVPR1AOXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |