Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | CNR2 | P34972 | 7/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.33 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GRK2 | P25098 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562540 | 1.00 | HDAC1 (0.39) | HDAC1HDAC8CNR2ALOX5MEN1 | |
| SCHEMBL8561158 | 0.84 | MAPT (0.35) | CNR2ALOX5MEN1KMT2ANTRK1 | |
| SCHEMBL8561161 | 0.84 | MAPT (0.35) | CNR2ALOX5MEN1KMT2ANTRK1 | |
| SCHEMBL8561600 | 0.77 | ALDH1A1 (0.34) | CNR2MEN1KMT2ANTRK1NPC1 | |
| SCHEMBL8561603 | 0.77 | ALDH1A1 (0.34) | CNR2MEN1KMT2ANTRK1NPC1 | |
| SCHEMBL8561601 | 0.76 | PPARA (0.36) | NPC1MAPTTSHRRAB9A | |
| SCHEMBL8561604 | 0.76 | PPARA (0.36) | NPC1MAPTTSHRRAB9A | |
| SCHEMBL25145277 | 0.74 | CNR2 (0.48) | CNR2MEN1KMT2ACNR1ABCC2 | |
| SCHEMBL27366620 | 0.74 | CNR2 (0.45) | CNR2CNR1ABCC2TSHR | |
| SCHEMBL9832588 | 0.68 | ALDH1A1 (0.47) | HDAC1HDAC8KMT2ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0695755-B1 | Pyrrolocarbazole | HOFFMANN LA ROCHE (CH) | 1998-10-21 | — | — | EP | disclosed |
| US-5721267-A | ANTICANCER AGENTS | SYNTEX (U.S.A.) INC. (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0695755-A1 | Pyrrolocarbazoles | F. Hoffmann-La Roche AG (CH) | 1996-02-07 | — | — | EP | disclosed |