Sugi Predict

Sugi Predict / Compounds / SCHEMBL856256

SCHEMBL856256

SCHEMBL856256

Nc1cc(Cl)c(Br)cc1C(=O)O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 3/20 0.50
▸ GLA P06280 1/20 0.50
▸ POLB P06746 4/20 0.47
▸ ALDH1A1 P00352 4/20 0.47
▸ GAA P10253 2/20 0.47
▸ HPGD P15428 1/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ CYP3A4 P08684 1/20 0.46
▸ IDO1 P14902 1/20 0.46
▸ KMT2A Q03164 2/20 0.44
▸ GFER P55789 1/20 0.44
▸ RXFP1 Q9HBX9 1/20 0.44
▸ MAPT P10636 3/20 0.42
▸ MCL1 Q07820 2/20 0.42
▸ TDP1 Q9NUW8 2/20 0.42
▸ MEN1 O00255 1/20 0.42
▸ USP2 O75604 1/20 0.42
▸ THRB P10828 1/20 0.42
▸ PKM P14618 1/20 0.42
▸ APEX1 P27695 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27650666 1.00 KDM4E (0.50) KDM4EGLAPOLBALDH1A1GAA
SCHEMBL30626196 0.92 KDM4E (0.50) KDM4EGLAPOLBALDH1A1GAA
SCHEMBL30077664 0.92 KDM4E (0.50) KDM4EGLAPOLBALDH1A1GAA
SCHEMBL7023673 0.92 KDM4E (0.50) KDM4EGLAPOLBALDH1A1GAA
SCHEMBL28838498 0.84 CA12 (0.50) KDM4EGLAPOLBALDH1A1GAA
SCHEMBL22701217 0.84 CA12 (0.42) POLBALDH1A1GAAHPGDL3MBTL1
SCHEMBL3031603 0.83 CYP3A4 (0.52) KDM4EGLAPOLBALDH1A1GAA
SCHEMBL1047232 0.83 KDM4E (0.57) KDM4EGLAPOLBALDH1A1GAA
SCHEMBL9081324 0.81 KDM4E (0.55) KDM4EGLAPOLBALDH1A1GAA
SCHEMBL2129971 0.81 CA12 (0.55) KDM4EPOLBALDH1A1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 161 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106986809-B Synthesis method of 5-bromo-6-chloro-3-indoxyl 广东省微生物研究所（广东省微生物分析检测中心） 2020-03-24 — — CN claimed
US-12473291-B2 Benzodiazepine compound, preparation method therefor, and use thereof in medicine WEST CHINA HOSPITAL, SICHUAN UNIVERSITY (CN) 2025-11-18 — — US disclosed
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2025-02-25 — — US disclosed
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-10-24 — — US disclosed
US-20240043441-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-02-08 — — US disclosed
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2024-01-23 — — US disclosed
US-20230357253-A1 AGONISTS OF STIMULATOR OF INTERFERON GENES STING THE SCRIPPS RESEARCH INSTITUTE 2023-11-09 — — US disclosed
US-20230357253-A1 AGONISTS OF STIMULATOR OF INTERFERON GENES STING THE SCRIPPS RESEARCH INSTITUTE 2023-11-09 — — US disclosed
US-20230357253-A1 AGONISTS OF STIMULATOR OF INTERFERON GENES STING THE SCRIPPS RESEARCH INSTITUTE 2023-11-09 — — US disclosed
CN-116940567-A Agonists of the interferon gene stimulator STING 斯克里普斯研究学院 2023-10-24 — — CN disclosed
WO-2005054238-A1 1H-IMIDAZO[4,5-C]QUINOLINE DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES NOVARTIS AG (CH) 2005-06-16 — — WO disclosed
WO-2005054237-A1 1H-IMIDAZOQUINOLINE DERIVATIVES AS PROTEIN KINASE INHIBITORS NOVARTIS AG (CH) 2005-06-16 — — WO disclosed
EP-0781767-B1 Process for producing isatoic anhydrides SUMITOMO CHEMICAL CO (JP) 2001-09-05 — — EP disclosed
US-5981749-A Process for producing isatoic anhydrides SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1999-11-09 — — US disclosed
US-5973145-A Process for producing isatoic anhydrides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-10-26 — — US disclosed
US-5795984-A Process for producing isatoic anhydrides SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1998-08-18 — — US disclosed
EP-0781767-A1 Process for producing isatoic anhydrides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-07-02 — — EP disclosed
EP-0216028-A2 Use of anthranilic-acid derivatives as anthelmintic medicaments HOECHST AKTIENGESELLSCHAFT (DE) 1987-04-01 — — EP disclosed
US-4214889-A Benzoxazine herbicides SANDOZ, INC. (US) 1980-07-29 — — US disclosed
US-4164407-A Benzoxazine herbicides SANDOZ, INC. (US) 1979-08-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C KRAS, NRAS, HRAS KDM4E 2534/4885GLA 2985/4885POLB 672/4885
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C KRAS, NRAS, HRAS KDM4E 3221/4885GLA 1400/4885POLB 603/4885
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS KDM4E 3221/4885GLA 1400/4885POLB 603/4885
US-20230357253-A1 AGONISTS OF STIMULATOR OF INTERFERON GENES STING STING1, IRF3, CGAS KDM4E 4074/4885GLA 2066/4885POLB 326/4885
US-20240043441-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS KDM4E 3220/4885GLA 942/4885POLB 639/4885
US-12473291-B2 Benzodiazepine compound, preparation method therefor, and use thereof in medicine GABRA1, GABRA4, GABRR1 KDM4E 833/4885GLA 4718/4885POLB 4123/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.