Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 17/20 | 0.35 |
| ▸ | RARA | P10276 | 17/20 | 0.35 |
| ▸ | RARG | P13631 | 16/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8666325 | 0.80 | RARB (0.34) | RARBRARARARGRXRANR2E1 | |
| SCHEMBL8333424 | 0.79 | RARA (0.48) | RARBRARARARGRXRANR2E1 | |
| SCHEMBL8333421 | 0.79 | RARA (0.48) | RARBRARARARGRXRANR2E1 | |
| SCHEMBL8664382 | 0.76 | RARB (0.44) | RARBRARARARGRXRANR2E1 | |
| SCHEMBL8561974 | 0.76 | RARB (0.54) | RARBRARARARGRXRANR2E1 | |
| SCHEMBL8666328 | 0.75 | RARA (0.36) | RARBRARARARGRXRANR2E1 | |
| SCHEMBL6818882 | 0.73 | RARB (0.48) | RARBRARARARGRXRANR2E1 | |
| SCHEMBL6238701 | 0.72 | RARA (0.60) | RARBRARARARGRXRANR2E1 | |
| SCHEMBL6238706 | 0.72 | RARA (0.60) | RARBRARARARGRXRANR2E1 | |
| SCHEMBL8331635 | 0.72 | PDK2 (0.46) | RARBRARARARGRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5808124-A | BINDING TO RETINOID RECEPTORS | ALLERGAN (US) | 1998-09-15 | — | — | US | disclosed |
| US-5741896-A | O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity | ALLERGAN (US) | 1998-04-21 | — | — | US | disclosed |