Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8567342 | 0.87 | NR1H4 (0.39) | NR1H4PTPN1ABCB1LMNACCR1 | |
| SCHEMBL9226094 | 0.86 | NR1H4 (0.35) | NR1H4PTPN1ABCB1LMNACCR1 | |
| SCHEMBL8564071 | 0.84 | SGMS2 (0.41) | NR1H4CCR1SGMS2 | |
| SCHEMBL8564707 | 0.83 | LTB4R (0.43) | NR1H4 | |
| SCHEMBL6762521 | 0.83 | NR1H4 (0.44) | NR1H4PTPN1LMNA | |
| SCHEMBL6897555 | 0.81 | NR1H4 (0.50) | NR1H4PTPN1ABCB1LMNAHTR2A | |
| SCHEMBL8560737 | 0.80 | NR1H4 (0.53) | NR1H4PTPN1ABCB1LMNACCR5 | |
| SCHEMBL6899274 | 0.79 | NR1H4 (0.48) | NR1H4PTPN1ABCB1LMNACCR5 | |
| SCHEMBL6759095 | 0.78 | NR1H4 (0.52) | NR1H4PTPN1ABCB1LMNACCR5 | |
| SCHEMBL6807773 | 0.78 | NR1H4 (0.47) | NR1H4PTPN1ABCB1LMNACCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544488-B1 | Substituted phenyl phenol leukotriene antagonists | LILLY CO ELI (US) | 1998-03-11 | — | — | EP | disclosed |
| WO-1996036347-A1 | USE OF LEUKOTRIENE ANTAGONISTS FOR ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1996-11-21 | — | — | WO | disclosed |
| EP-0743064-A1 | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease | ELI LILLY AND COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |
| US-5462954-A | Antiinflammatory, antiallergens; treating asthma | ELI LILLY AND COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0544488-A2 | Substituted phenyl phenol leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |