Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8568797 | 0.88 | MTNR1A (0.39) | EPHX2MTNR1AMTNR1BSLC6A2SLC6A4 | |
| SCHEMBL8569796 | 0.85 | EPHX2 (0.42) | EPHX2MTNR1AMTNR1BSLC6A2SLC6A4 | |
| SCHEMBL8569787 | 0.85 | EPHX2 (0.42) | EPHX2MTNR1AMTNR1BSLC6A2SLC6A4 | |
| SCHEMBL12610368 | 0.81 | MTNR1A (0.44) | EPHX2MTNR1AMTNR1BBRD4CREBBP | |
| SCHEMBL29332740 | 0.81 | MTNR1A (0.44) | EPHX2MTNR1AMTNR1BBRD4CREBBP | |
| SCHEMBL881106 | 0.81 | MTNR1A (0.44) | EPHX2MTNR1AMTNR1BBRD4CREBBP | |
| SCHEMBL7685258 | 0.78 | IDO1 (0.41) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8568438 | 0.74 | MTNR1A (0.48) | EPHX2MTNR1AMTNR1BBRD4CREBBP | |
| SCHEMBL8568440 | 0.74 | MTNR1A (0.48) | EPHX2MTNR1AMTNR1BBRD4CREBBP | |
| SCHEMBL8568444 | 0.74 | MTNR1A (0.48) | EPHX2MTNR1AMTNR1BBRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |