SCHEMBL8563058

SCHEMBL8563058

CCOC(=O)Oc1cc(NC(C)=O)cnc1OC(=O)OCC

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.43
RORC P51449 3/20 0.42
KMT2A Q03164 2/20 0.41
MEN1 O00255 1/20 0.41
LMNA P02545 1/20 0.41
CYP1A2 P05177 1/20 0.41
MAPT P10636 2/20 0.40
CDK1 P06493 2/20 0.39
CDK4 P11802 2/20 0.39
CCNE1 P24864 2/20 0.39
CDK2 P24941 2/20 0.39
PPID Q08752 1/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
CYP11B1 P15538 1/20 0.37
CYP11B2 P19099 1/20 0.37
CCNB2 O95067 1/20 0.37
CCNE2 O96020 1/20 0.37
CCNB1 P14635 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9234126 0.86 CYP1A2 (0.42) RORCKMT2AMEN1LMNACYP1A2
SCHEMBL9678280 0.81 CUL4A (0.40) KMT2AMEN1LMNAMAPTCUL4A
SCHEMBL9678306 0.78 CUL4A (0.39) KMT2ACUL4A
SCHEMBL9678275 0.78 CUL4A (0.41) CYP1A2MAPTRAB9ASMN1; SMN2CUL4A
SCHEMBL8566455 0.78 SMN1; SMN2 (0.36) KMT2AMEN1LMNACYP1A2MAPT
SCHEMBL9233277 0.77 DPP4 (0.40) TDP1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL7608571 0.75 CUL4A (0.36) CUL4A
SCHEMBL8560861 0.75 ALDH1A1 (0.44) KMT2AMEN1LMNAMAPTSMN1; SMN2
SCHEMBL8558386 0.74 MAPT (0.46) KMT2AMEN1LMNACYP1A2MAPT
SCHEMBL30675553 0.73 PIK3CG (0.49) TDP1RORCLMNAMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0663399-B1 Pyridine-2,3-dicarboxylic imides, process for their preparation and their use to control the growth of unwanted plants BASF AG (DE) 1998-06-10 EP claimed
EP-0663399-B1 Pyridine-2,3-dicarboxylic imides, process for their preparation and their use to control the growth of unwanted plants BASF AG (DE) 1998-06-10 EP disclosed