Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 3/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.38 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14263834 | 0.86 | TNF (0.57) | HPGDMAPTTNFALDH1A1TSHR | |
| SCHEMBL4991751 | 0.84 | LMNA (0.45) | HPGDMAPTTNFALDH1A1HSD17B10 | |
| SCHEMBL9699493 | 0.76 | SMN1; SMN2 (0.39) | HPGDMAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL9303969 | 0.73 | KCNH2 (0.60) | MAPTALDH1A1USP2TP53LMNA | |
| SCHEMBL8162459 | 0.73 | SSTR5 (0.48) | MAPTUSP2TP53LMNACYP1A2 | |
| SCHEMBL13258286 | 0.73 | TP53 (0.67) | HPGDMAPTTNFALDH1A1KDM4E | |
| SCHEMBL12768325 | 0.73 | NPC1 (0.72) | MAPTALDH1A1KDM4ETSHRGALR3 | |
| Water SCHEMBL9303347 | 0.72 | KCNH2 (0.48) | MAPTUSP2TP53LMNACYP1A2 | |
| SCHEMBL9304114 | 0.72 | HRH1 (0.42) | TSHRLMNACYP2D6 | |
| Water SCHEMBL9302746 | 0.72 | KCNH2 (0.48) | MAPTUSP2TP53LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539421-B1 | NOVEL OXAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 1998-09-23 | — | — | EP | disclosed |
| US-5278165-A | Oxazolyl imidazol[4,5-b]pyridin and pyrimidine compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-01-11 | — | — | US | disclosed |
| US-5217980-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-06-08 | — | — | US | disclosed |