Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563530 | 0.85 | ALDH1A1 (0.35) | KDM4ECYP1A2CYP2C19ALDH1A1ENPP1 | |
| SCHEMBL8565727 | 0.83 | KDM4E (0.33) | KDM4ECYP1A2CYP2C19ALDH1A1TSHR | |
| SCHEMBL8326771 | 0.82 | SRC (0.42) | KDM4EGAAMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL8326372 | 0.81 | TSHR (0.40) | KDM4ECYP1A2ALDH1A1TSHRGAA | |
| SCHEMBL8326185 | 0.80 | SLC2A1 (0.40) | TSHRHTTLMNAMEN1KMT2A | |
| SCHEMBL8327645 | 0.80 | KMT2A (0.51) | KDM4EALDH1A1TSHRGAAMAPT | |
| SCHEMBL8321420 | 0.76 | SMN1; SMN2 (0.39) | KDM4ECYP1A2CYP2C19ALDH1A1ENPP1 | |
| SCHEMBL8561182 | 0.75 | HSD17B10 (0.36) | KDM4ECYP1A2CYP2C19ALDH1A1GRM5 | |
| SCHEMBL8567944 | 0.74 | KDM4E (0.38) | KDM4ECYP1A2CYP2C19ALDH1A1ENPP1 | |
| SCHEMBL8327213 | 0.72 | DPP4 (0.49) | KDM4EALDH1A1TSHRMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |
| WO-1993013097-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |