Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561182 | 0.85 | HSD17B10 (0.36) | KDM4EMAPK1ALOX5ALDH1A1GAA | |
| SCHEMBL8563128 | 0.83 | KDM4E (0.37) | KDM4EMAPK1ALDH1A1GAAPDPK1 | |
| SCHEMBL8324245 | 0.81 | TSHR (0.42) | KDM4EALDH1A1DPP4CYP1A2CYP3A4 | |
| SCHEMBL8328855 | 0.80 | DPP4 (0.40) | MAPK1DPP4CYP3A4LMNATSHR | |
| SCHEMBL8322260 | 0.80 | DPP4 (0.48) | KDM4EDPP4TSHRMAPT | |
| SCHEMBL8562829 | 0.79 | ALDH1A1 (0.38) | ALDH1A1DPP4TSHRTDP1HPGD | |
| SCHEMBL9258966 | 0.78 | DPP4 (0.36) | ALDH1A1DPP4MEN1KMT2ACYP3A4 | |
| SCHEMBL8329040 | 0.77 | KMT2A (0.39) | KDM4EMAPK1ALOX5ALDH1A1GAA | |
| SCHEMBL8562455 | 0.75 | GAA (0.34) | KDM4EMAPK1ALOX5ALDH1A1GAA | |
| SCHEMBL8563530 | 0.75 | ALDH1A1 (0.35) | KDM4EALDH1A1GAADPP4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |
| EP-0618916-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | Knoll AG (DE) | 1994-10-12 | — | — | EP | disclosed |
| WO-1993013097-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |