Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563144 | 0.86 | AGTR1 (0.70) | PPARG | |
| SCHEMBL8567737 | 0.84 | PPARG (0.45) | PPARG | |
| SCHEMBL8543694 | 0.84 | AGTR2 (0.80) | PPARG | |
| SCHEMBL9638344 | 0.82 | ABCB11 (0.56) | PPARG | |
| SCHEMBL7012683 | 0.82 | — | — | |
| SCHEMBL8393405 | 0.82 | PPARG (0.84) | PPARG | |
| SCHEMBL8564903 | 0.82 | AGTR2 (0.48) | — | |
| SCHEMBL8566614 | 0.81 | AGTR2 (0.63) | — | |
| SCHEMBL684043 | 0.81 | AGTR2 (0.59) | — | |
| SCHEMBL7014227 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603001-B1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1998-08-26 | — | — | EP | claimed |
| US-5459148-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1995-10-17 | — | — | US | claimed |
| EP-0603001-A1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO COMPANY LIMITED (JP) | 1994-06-22 | — | — | EP | claimed |
| EP-0603001-B1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1998-08-26 | — | — | EP | disclosed |
| US-5459148-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0603001-A1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO COMPANY LIMITED (JP) | 1994-06-22 | — | — | EP | disclosed |