Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | PGR | P06401 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALPL | P05186 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | IL1RN | P18510 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559695 | 0.81 | ALDH1A1 (0.50) | ALDH1A1TP53TDP1ALPLKMT2A | |
| SCHEMBL3769126 | 0.79 | PGR (0.73) | ALDH1A1PGRTDP1MAPTKMT2A | |
| SCHEMBL8212413 | 0.76 | LMNA (0.49) | ALDH1A1TP53MAPTKMT2ALMNA | |
| SCHEMBL29114599 | 0.75 | CA1 (0.53) | ALDH1A1TP53TDP1ALPLMAPT | |
| SCHEMBL29498577 | 0.75 | ALDH1A1 (0.51) | ALDH1A1PGRTP53TDP1ALPL | |
| SCHEMBL15544714 | 0.75 | SMN1; SMN2 (0.56) | ALDH1A1ALPLKMT2ALMNAMEN1 | |
| SCHEMBL17737761 | 0.74 | PRKD3 (0.59) | ALDH1A1PGRTP53TDP1KMT2A | |
| SCHEMBL8323021 | 0.73 | ALDH1A1 (0.47) | ALDH1A1TP53MAPTKMT2ALMNA | |
| SCHEMBL31696798 | 0.73 | MAPK1 (0.70) | ALDH1A1PGRTDP1ALPLMAPT | |
| SCHEMBL528302 | 0.73 | LMNA (0.52) | ALDH1A1PGRTP53TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| US-5459138-A | Dysfunctions of glutamatergic neurotransmission associated with learning and memory | ADIR ET COMPAGNIE (FR) | 1995-10-17 | — | — | US | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |