Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 3/20 | 0.45 |
| ▸ | PDE4A | P27815 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8531984 | 0.78 | ACHE (0.52) | PDE4ANPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL4167756 | 0.78 | CA12 (0.52) | PDE4ANPC1RAB9APDE4BPDE4C | |
| SCHEMBL28170408 | 0.74 | CA2 (0.68) | NPC1RAB9APOLBALDH1A1KDM4E | |
| SCHEMBL119395 | 0.74 | CA2 (0.68) | NPC1RAB9APOLBALDH1A1KDM4E | |
| SCHEMBL29997296 | 0.74 | CA2 (0.68) | NPC1RAB9APOLBALDH1A1KDM4E | |
| SCHEMBL1312009 | 0.74 | MAPT (0.54) | PDE4APOLBALDH1A1HSD17B10HPGD | |
| Methane SCHEMBL7067208 | 0.73 | CA2 (0.65) | NPC1RAB9APOLBALDH1A1KDM4E | |
| Methyl Alcohol SCHEMBL28203224 | 0.73 | CA2 (0.65) | NPC1RAB9APOLBALDH1A1KDM4E | |
| SCHEMBL5322067 | 0.72 | PDE4A (0.50) | PDE4ANPC1RAB9APDE4BPDE4C | |
| SCHEMBL10449130 | 0.72 | APP (0.46) | FYNALDH1A1KDM4EHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823908-A1 | PYRIDO 2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1998-02-18 | — | — | EP | disclosed |
| WO-1996034867-A1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1996-11-07 | — | — | WO | disclosed |