Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 6/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ATP4A | P20648 | 2/20 | 0.39 |
| ▸ | ATP4B | P51164 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569938 | 0.80 | PARP1 (0.49) | HTR3EHTR3BHTR1AHTR3AHTR3D | |
| SCHEMBL8563514 | 0.73 | HTR3E (0.65) | HTR3EHTR3BHTR1AHTR3AHTR3D | |
| SCHEMBL13711924 | 0.73 | PARP1 (0.61) | PARP1CHEK1TP53 | |
| SCHEMBL8565857 | 0.72 | PARP1 (0.53) | PARP1TP53 | |
| SCHEMBL12750394 | 0.71 | PARP1 (0.54) | PARP1ADORA3 | |
| SCHEMBL2194788 | 0.71 | HCAR1 (0.48) | PKMGRM5LOXL2 | |
| SCHEMBL2262510 | 0.70 | PDE7A (0.41) | PKMLOXL2 | |
| SCHEMBL2194820 | 0.70 | HCAR1 (0.47) | PKMGRM5LOXL2 | |
| SCHEMBL30809703 | 0.69 | PDE2A (0.67) | HTR3EHTR3BHTR1AHTR3AHTR3D | |
| SCHEMBL8566230 | 0.69 | PDE2A (0.67) | HTR3EHTR3BHTR1AHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | disclosed |
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | disclosed |
| EP-0623620-A1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR ET COMPAGNIE (FR) | 1994-11-09 | — | — | EP | disclosed |