Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562397 | 0.86 | POLB (0.41) | GAATDP1MEN1KMT2ALMNA | |
| SCHEMBL6046251 | 0.86 | ESR1 (0.50) | KDM4EL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL11117708 | 0.84 | ESR1 (0.52) | GAAKDM4ETDP1L3MBTL1KMT2A | |
| SCHEMBL4517176 | 0.82 | L3MBTL1 (0.49) | GAATDP1L3MBTL1MEN1KMT2A | |
| SCHEMBL13084199 | 0.82 | GAA (0.44) | GAAKDM4ETDP1L3MBTL1MEN1 | |
| SCHEMBL11039440 | 0.82 | LMNA (0.53) | GAAKDM4ETDP1L3MBTL1MEN1 | |
| SCHEMBL6293 | 0.82 | MAPT (0.46) | GAAKDM4ETDP1L3MBTL1MEN1 | |
| SCHEMBL23027214 | 0.81 | GAA (0.62) | GAAKDM4ETDP1L3MBTL1MEN1 | |
| SCHEMBL805646 | 0.81 | GAA (0.62) | GAAKDM4ETDP1L3MBTL1MEN1 | |
| SCHEMBL15030577 | 0.81 | MMP8 (0.51) | TDP1MEN1KMT2ALMNAOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114605304-A | Method for synthesizing (+/-) -ethyl 2- (4- (1-oxoisoindol-2-yl) phenyl) butyrate | 杭州中美华东制药有限公司 | 2022-06-10 | — | — | CN | disclosed |
| US-5717094-A | 6-THIOCHROMANYL-ETHYNE, 6-CHROMANYL ETHYNE AND 6-TETRAHYDROQUINOLINYL ETHYNE OR THEIR METAL SALTS ARE REACTED WITH SUITABLE HALO SUBSTITUTED PHENYL OR HETEROARYL COMPUNDS | ALLERGAN (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0419132-B1 | Process and intermediates for preparing compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity | ALLERGAN INC (US) | 1995-09-06 | — | — | EP | disclosed |
| US-5248777-A | Inhibitors of ornithine decarboxylase | ALLERGAN, INC. (US) | 1993-09-28 | — | — | US | disclosed |
| US-5053523-A | Chemical intermediate for compounds having retinoic acid-like activity | ALLERGAN, INC. (US) | 1991-10-01 | — | — | US | disclosed |
| US-5023341-A | Acetylene thiochroman | ALLERGAN, INC. (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0419132-A2 | Process and intermediates for preparing compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity | ALLERGAN, INC. (US) | 1991-03-27 | — | — | EP | disclosed |