SCHEMBL17865779

SCHEMBL17865779

CC(C)(C)NC(=O)c1ccc(C(=O)NC(C)(C)C)cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.58
HTT P42858 1/20 0.58
HDAC1 Q13547 1/20 0.52
CYP2C9 P11712 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
EPHX1 P07099 1/20 0.52
MAPT P10636 2/20 0.51
SIRT2 Q8IXJ6 1/20 0.51
POLB P06746 2/20 0.50
PRKAB2 O43741 1/20 0.50
PRKAG1 P54619 1/20 0.50
PRKAA2 P54646 1/20 0.50
PRKAA1 Q13131 1/20 0.50
PRKAG3 Q9UGI9 1/20 0.50
PRKAG2 Q9UGJ0 1/20 0.50
PRKAB1 Q9Y478 1/20 0.50
AOC3 Q16853 2/20 0.49
JAK2 O60674 1/20 0.49
MAOB P27338 1/20 0.49
RIPK1 Q13546 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2522600 0.93 LMNA (0.53) LMNAHTTHDAC1CYP2C9SMN1; SMN2
SCHEMBL2264435 0.91 ALDH1A1 (0.61) LMNAHTTHDAC1SMN1; SMN2MAPT
SCHEMBL25753418 0.91 LMNA (0.51) LMNAHTTHDAC1CYP2C9SMN1; SMN2
SCHEMBL13762029 0.91 HDAC1 (0.67) LMNAHTTHDAC1SMN1; SMN2MAPT
SCHEMBL162828 0.91 TSHR (0.54) LMNAHTTCYP2C9SMN1; SMN2MAPT
SCHEMBL13701770 0.91 HDAC2 (0.59) LMNAHTTSMN1; SMN2EPHX1MAPT
SCHEMBL3716265 0.91 SRD5A2 (0.53) LMNAHTTCYP2C9SMN1; SMN2EPHX1
SCHEMBL691761 0.89 KMT2A (0.56) LMNAHTTHDAC1CYP2C9POLB
SCHEMBL1176575 0.89 LMNA (0.50) LMNAHTTHDAC1CYP2C9SMN1; SMN2
SCHEMBL21016381 0.89 EPHX2 (0.51) LMNAHTTCYP2C9SMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240209019-A1 COMPOUNDS AND METHODS FOR TREATING HYPERKALEMIA ARDELYX, INC. (US) 2024-06-27 US disclosed
US-12019371-B2 Photosensitive composition, film, color filter, solid-state imaging element, and image display device FUJIFILM CORPORATION (JP) 2024-06-25 US disclosed
US-11858959-B2 Glycyrrhetinic acid derivatives for use in treating hyperkalemia ARDELYX, INC. (US) 2024-01-02 US disclosed
US-11768319-B2 Glycyrrhetinic acid derivatives for treating hyperkalemia ARDELYX, INC. (US) 2023-09-26 US disclosed
US-20230277523-A1 METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. (US) 2023-09-07 US disclosed
US-20230273354-A1 GLYCYRRHETINIC ACID DERIVATIVES FOR TREATING HYPERKALEMIA ARDELYX, INC. (US) 2023-08-31 US disclosed
EP-3475085-B1 MULTILAYER FILMS AND PACKAGES FORMED FROM SAME DOW GLOBAL TECHNOLOGIES LLC (US) 2023-07-05 EP disclosed
CN-109195795-B Multilayer film and package formed therefrom 陶氏环球技术有限责任公司 2022-02-18 CN disclosed
US-20210223436-A1 STRUCTURAL BODY, SOLID-STATE IMAGING ELEMENT, AND IMAGE DISPLAY DEVICE FUJIFILM CORPORATION (JP) 2021-07-22 US disclosed
US-20210186953-A1 NHE3-BINDING COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. (US) 2021-06-24 US disclosed
US-20180022894-A1 POLYETHYLENE COMPOSITIONS WITH IMPROVED OPTICAL PROPERTIES DOW GLOBAL TECHNOLOGIES LLC (US) 2018-01-25 US disclosed
US-20170368004-A1 COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS ARDELYX, INC. 2017-12-28 US disclosed
EP-3260295-A1 MULTILAYER FILMS AND PACKAGES FORMED FROM SAME Dow Global Technologies LLC (US) 2017-12-27 EP disclosed
EP-3237521-A1 POLYETHYLENE COMPOSITIONS WITH IMPROVED OPTICAL PROPERTIES Dow Global Technologies LLC (US) 2017-11-01 EP disclosed
US-20170210736-A1 PHENYL TETRAHYDROISOQUINOLINE COMPOUND SUBSTITUTED WITH HETEROARYL TAISHO PHARMACEUTICAL CO., LTD (JP) 2017-07-27 US disclosed
US-20170210736-A1 PHENYL TETRAHYDROISOQUINOLINE COMPOUND SUBSTITUTED WITH HETEROARYL TAISHO PHARMACEUTICAL CO., LTD (JP) 2017-07-27 US disclosed
WO-2016105610-A1 POLYETHYLENE COMPOSITIONS WITH IMPROVED OPTICAL PROPERTIES DOW GLOBAL TECHNOLOGIES LLC (US) 2016-06-30 WO disclosed
EP-3037466-A1 Polyethylene compositions with improved optical properties Dow Global Technologies LLC (US) 2016-06-29 EP disclosed
US-20160067242-A1 NHE3-BINDING COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. 2016-03-10 US disclosed
US-20150336892-A1 COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS ARDELYX, INC (US) 2015-11-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240209019-A1 COMPOUNDS AND METHODS FOR TREATING HYPERKALEMIA REN, NHERF1, KCNJ11 LMNA 1098/4885HTT 4337/4885HDAC1 1081/4885
US-20160067242-A1 NHE3-BINDING COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT SLC34A3, SLC34A2, SLC34A1 LMNA 4327/4885HTT 2581/4885HDAC1 1957/4885
US-20150336892-A1 COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS SLC10A1, SLC10A2, FABP2 LMNA 3770/4885HTT 1823/4885HDAC1 1556/4885
US-11768319-B2 Glycyrrhetinic acid derivatives for treating hyperkalemia HSD11B2, HSD11B1, HSD3B2 LMNA 2542/4885HTT 4071/4885HDAC1 1171/4885
US-20180022894-A1 POLYETHYLENE COMPOSITIONS WITH IMPROVED OPTICAL PROPERTIES PARG, PARN, FHIT LMNA 235/4885HTT 232/4885HDAC1 1977/4885
US-20170210736-A1 PHENYL TETRAHYDROISOQUINOLINE COMPOUND SUBSTITUTED WITH HETEROARYL NHERF1, SLC9A3, SLC26A3 LMNA 3991/4885HTT 2014/4885HDAC1 273/4885
US-20230277523-A1 METHODS FOR INHIBITING PHOSPHATE TRANSPORT SLC34A3, SLC34A2, SLC34A1 LMNA 3836/4885HTT 2060/4885HDAC1 2068/4885
US-20230273354-A1 GLYCYRRHETINIC ACID DERIVATIVES FOR TREATING HYPERKALEMIA GRHPR, REN, GRK5 LMNA 2166/4885HTT 3334/4885HDAC1 2898/4885
US-20170368004-A1 COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS SLC10A1, SLC10A2, FABP2 LMNA 3770/4885HTT 1823/4885HDAC1 1556/4885
US-11858959-B2 Glycyrrhetinic acid derivatives for use in treating hyperkalemia HSD11B2, HSD11B1, NR3C2 LMNA 3455/4885HTT 4344/4885HDAC1 1016/4885
US-20210186953-A1 NHE3-BINDING COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT SLC34A3, SLC34A2, SLC34A1 LMNA 4327/4885HTT 2581/4885HDAC1 1957/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.