Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20240487 | 0.76 | POLB (0.38) | RAB9AMAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL24100191 | 0.75 | GBA1 (0.53) | GBA1RAB9AMAPTALDH1A1NPC1 | |
| SCHEMBL1180593 | 0.73 | GBA1 (0.50) | GBA1RAB9AMAPTALDH1A1NPC1 | |
| SCHEMBL2714877 | 0.73 | GBA1 (0.47) | GBA1RAB9AMAPTALDH1A1NPC1 | |
| SCHEMBL1691033 | 0.73 | GRM4 (0.35) | RAB9AMAPTALDH1A1NPC1KDM4E | |
| SCHEMBL1423531 | 0.72 | OPRM1 (0.38) | RAB9AALDH1A1KMT2AKDM4ELMNA | |
| SCHEMBL28794544 | 0.71 | GBA1 (0.44) | GBA1RAB9AMAPTALDH1A1NPC1 | |
| SCHEMBL1292323 | 0.69 | KDM4E (0.34) | KMT2AKDM4EL3MBTL1 | |
| SCHEMBL4086856 | 0.69 | GBA1 (0.44) | GBA1RAB9AMAPTALDH1A1NPC1 | |
| SCHEMBL17316578 | 0.66 | GBA1 (1.00) | GBA1RAB9AMAPTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104114552-A | Substituted triazolopyridines and their use as ttk inhibitors | BAYER IP GMBH | 2014-10-22 | — | — | CN | disclosed |
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |
| CN-102197031-A | Substituted 5-aminopyrazoles and use thereof | BAYER SCHERING PHARMA AG | 2011-09-21 | — | — | CN | disclosed |