Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 12/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SSTR2 | P30874 | 4/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 4/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5888042 | 0.81 | GBA1 (0.49) | GBA1RAD52ALDH1A1MAPTRAB9A | |
| SCHEMBL4078040 | 0.78 | KMT2A (0.42) | NPC1ALDH1A1RAB9AKMT2APLAU | |
| SCHEMBL3177206 | 0.77 | SMN1; SMN2 (0.44) | GBA1RAD52NPC1ALDH1A1MAPT | |
| SCHEMBL6231791 | 0.77 | AOC3 (0.40) | GBA1RAD52NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15205756 | 0.76 | GBA1 (0.61) | GBA1RAD52NPC1ALDH1A1MAPT | |
| SCHEMBL4096326 | 0.75 | POLB (0.36) | NPC1ALDH1A1RAB9ASMN1; SMN2PLAU | |
| SCHEMBL5255404 | 0.73 | GBA1 (0.53) | GBA1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL4086338 | 0.72 | — | — | |
| SCHEMBL18584256 | 0.71 | ALDH1A1 (0.37) | GBA1RAD52ALDH1A1KMT2ASSTR2 | |
| SCHEMBL856442 | 0.69 | GBA1 (0.48) | GBA1RAD52NPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053449-A1 | THIAZOLES WHICH POTENTIATE AMPA RECEPTOR AND MEDICINAL USES THEREOF | GLAXO GROUP LIMITED (GB) | 2009-04-30 | — | — | WO | disclosed |