Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL920416 | 0.90 | FFAR1 (0.40) | LTA4HFFAR1THRBALDH1A1 | |
| SCHEMBL922033 | 0.85 | LTA4H (0.41) | LTA4HFFAR1 | |
| SCHEMBL921443 | 0.82 | LTA4H (0.43) | LTA4HS1PR1S1PR3CA1CA2 | |
| SCHEMBL5614714 | 0.81 | LTA4H (0.66) | LTA4HFFAR1PPARGALDH1A1HPGD | |
| SCHEMBL145761 | 0.81 | LTA4H (0.52) | LTA4HS1PR1S1PR3CA1CA2 | |
| SCHEMBL920898 | 0.77 | LTA4H (0.63) | LTA4HCA1CA2 | |
| SCHEMBL4907042 | 0.77 | LTA4H (0.63) | LTA4HFFAR1PPARG | |
| SCHEMBL5667215 | 0.76 | LTA4H (0.65) | LTA4HFFAR1ALDH1A1HSD17B10 | |
| SCHEMBL131741 | 0.76 | LTA4H (0.53) | LTA4HCA1CA2ALDH1A1 | |
| SCHEMBL16933886 | 0.76 | RARB (0.55) | LTA4HS1PR1S1PR3CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| EP-0833629-A4 | ARYL ACRYLIC ACID DERIVATIVES USEFUL AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ONTOGEN CORP (US) | 1998-09-16 | — | — | EP | disclosed |
| US-5770620-A | ENZYME INHIBITOR AS IMMUNOMODULATORS | ONTOGEN CORPORATION (US) | 1998-06-23 | — | — | US | disclosed |
| EP-0833629-A2 | ARYL ACRYLIC ACID DERIVATIVES USEFUL AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ONTOGEN CORPORATION (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1997008934-A2 | ARYL ACRYLIC ACID DERIVATIVES USEFUL AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ONTOGEN CORPORATION (US) | 1997-03-13 | — | — | WO | disclosed |