Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | ELANE | P08246 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.54 |
| ▸ | GLS | O94925 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | THRA | P10827 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565931 | 0.98 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2ELANEGAA | |
| SCHEMBL8564239 | 0.95 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2ELANEGAA | |
| SCHEMBL717987 | 0.91 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2ELANEGAA | |
| SCHEMBL23894744 | 0.87 | LMNA (0.57) | NPC1RAB9ASMN1; SMN2ELANEGAA | |
| SCHEMBL9860348 | 0.87 | MAPT (0.59) | NPC1RAB9ASMN1; SMN2FFAR1MAPT | |
| SCHEMBL1248565 | 0.86 | THRB (0.68) | SMN1; SMN2MAPTALDH1A1KMT2ATHRB | |
| SCHEMBL7930197 | 0.86 | THRB (0.68) | SMN1; SMN2MAPTALDH1A1KMT2ATHRB | |
| SCHEMBL8086401 | 0.86 | THRB (0.68) | SMN1; SMN2MAPTALDH1A1KMT2ATHRB | |
| SCHEMBL8080349 | 0.86 | THRB (0.68) | SMN1; SMN2MAPTALDH1A1KMT2ATHRB | |
| SCHEMBL8072596 | 0.86 | THRB (0.68) | SMN1; SMN2MAPTALDH1A1KMT2ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843997-A | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1998-12-01 | — | — | US | disclosed |
| US-5576323-A | CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| EP-0658539-A1 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1995-06-21 | — | — | EP | disclosed |