Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | ELANE | P08246 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | PPARA | Q07869 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | GLS | O94925 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565931 | 0.96 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2ELANEGAA | |
| SCHEMBL8564694 | 0.95 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2ELANEGAA | |
| SCHEMBL717987 | 0.93 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2ELANEGAA | |
| SCHEMBL23894744 | 0.93 | LMNA (0.57) | NPC1RAB9ASMN1; SMN2ELANEGAA | |
| SCHEMBL9102645 | 0.86 | HSD17B10 (0.67) | NPC1RAB9ASMN1; SMN2ELANEGAA | |
| SCHEMBL12305405 | 0.86 | CALM1 (0.62) | SMN1; SMN2LMNAPOLB | |
| SCHEMBL531085 | 0.85 | ELANE (0.61) | NPC1RAB9ASMN1; SMN2ELANEGAA | |
| SCHEMBL9081470 | 0.85 | LMNA (0.61) | NPC1RAB9ASMN1; SMN2ELANEGAA | |
| SCHEMBL1415501 | 0.84 | THRB (0.61) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL5537021 | 0.84 | THRB (0.53) | NPC1RAB9ASMN1; SMN2ELANEGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843997-A | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1998-12-01 | — | — | US | disclosed |
| US-5576323-A | CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| EP-0658539-A1 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1995-06-21 | — | — | EP | disclosed |