Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RHOA | P61586 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL396525 | 0.85 | NCF1 (0.61) | NCF1RAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL29833517 | 0.85 | NCF1 (0.61) | NCF1RAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL10458402 | 0.80 | NCF1 (0.71) | NCF1RAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL30760998 | 0.80 | NCF1 (0.71) | NCF1RAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL1703350 | 0.80 | NCF1 (0.55) | NCF1RAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL4494871 | 0.79 | KMT2A (0.58) | NCF1RAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL12431347 | 0.79 | NCF1 (0.58) | NCF1RAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL4812645 | 0.79 | NCF1 (0.53) | NCF1RAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL29110577 | 0.79 | NPC1 (0.58) | NCF1RAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL31098987 | 0.75 | RAB9A (0.61) | NCF1RAB9ANPC1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |