SCHEMBL8565101

SCHEMBL8565101

Cc1cc(Oc2ccc(N)cc2)c(C(C)(C)C)cc1C.O=C1C=CC(=O)N1.O=C1C=CC(=O)N1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.40
MAPT P10636 5/20 0.40
RAB9A P51151 3/20 0.40
NPC1 O15118 2/20 0.40
HPGD P15428 1/20 0.40
MAPK1 P28482 1/20 0.40
NR1H4 Q96RI1 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.37
TEAD4 Q15561 1/20 0.36
TDP1 Q9NUW8 2/20 0.35
POLB P06746 2/20 0.35
CYP3A4 P08684 1/20 0.33
TSHR P16473 1/20 0.33
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
ESRRA P11474 1/20 0.32
MITF O75030 1/20 0.32
GAA P10253 1/20 0.32
GFER P55789 1/20 0.32
NLRP1 Q9C000 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8561275 0.86 NPC1 (0.33) ALDH1A1MAPTRAB9ANPC1HPGD
SCHEMBL8565147 0.84 MAPT (0.32) ALDH1A1MAPTRAB9ANPC1HPGD
SCHEMBL1353357 0.78 ALDH1A1 (0.57) ALDH1A1MAPTRAB9ANPC1HPGD
SCHEMBL8564678 0.76 ALDH1A1 (0.48) ALDH1A1MAPTRAB9ANPC1HPGD
SCHEMBL14865712 0.75 TEAD4 (0.60) ALDH1A1MAPTRAB9ANPC1HPGD
SCHEMBL8990279 0.75 ALDH1A1 (0.45) ALDH1A1MAPTRAB9ANPC1HPGD
SCHEMBL30176246 0.74 ALDH1A1 (0.56) ALDH1A1MAPTRAB9ANPC1HPGD
SCHEMBL7941025 0.74 ALDH1A1 (0.56) ALDH1A1MAPTRAB9ANPC1HPGD
SCHEMBL8539341 0.70 MAPT (0.39) ALDH1A1MAPTRAB9ANPC1HPGD
SCHEMBL8644083 0.69 ALDH1A1 (0.50) ALDH1A1MAPTRAB9ANPC1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5780145-A CURED EPXOY AND OR IMIDE RESINS WITH FILLERS AND GLOBULAR POWDER WITH SPECIFIC PARTICLE SIZE USED AS A SEALING MATERIALS FOR SEMICONDUCTORS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-07-14 US disclosed
US-5719225-A RESIN COMPOSITION CONTAINING FILLER COMPRISING GLOBULAR POWDERS OF DIFFERENT PARTICLE SIZES IN SPECIFIED RATIOS SUMITOMO CHEMICAL COMPANY, LTD. (JP) 1998-02-17 US disclosed