Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7217081 | 1.00 | PTGS2 (0.62) | PTGS2PTGS1ALDH1A1NR1I3KDM4E | |
| SCHEMBL7218055 | 0.91 | PTGS2 (0.64) | PTGS2PTGS1NR1I3HDAC6 | |
| SCHEMBL7222836 | 0.88 | ALDH1A1 (0.54) | PTGS2PTGS1ALDH1A1KDM4EHPGD | |
| SCHEMBL7221860 | 0.85 | PTGS2 (0.71) | PTGS2PTGS1ALDH1A1NR1I3KDM4E | |
| SCHEMBL22342526 | 0.84 | ALDH1A1 (0.61) | ALDH1A1NR1I3KDM4EHPGDMAPK13 | |
| SCHEMBL7218478 | 0.83 | PTGS2 (0.60) | PTGS2PTGS1ALDH1A1KDM4EHPGD | |
| SCHEMBL22342529 | 0.83 | ALDH1A1 (0.57) | ALDH1A1NR1I3KDM4EHPGDMAPK13 | |
| SCHEMBL7216602 | 0.82 | PTGS2 (0.56) | PTGS2PTGS1ALDH1A1NR1I3KDM4E | |
| SCHEMBL7217160 | 0.82 | PTGS2 (0.56) | PTGS2PTGS1ALDH1A1NR1I3KDM4E | |
| SCHEMBL7216551 | 0.82 | PTGS2 (0.52) | PTGS2PTGS1NR1I3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819127-A1 | IMIDAZO [1,2-a]PYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031509-A1 | IMIDAZO[1,2-a]PYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1996-10-10 | — | — | WO | disclosed |