Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.73 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.73 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9209866 | 0.89 | AGTR1 (0.66) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL293 | 0.87 | AGTR1 (0.73) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL24360483 | 0.85 | AGTR1 (0.70) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL11100306 | 0.85 | AGTR1 (0.72) | AGTR1AGTR2 | |
| SCHEMBL29486822 | 0.84 | AGTR1 (1.00) | AGTR1AGTR2 | |
| SCHEMBL89 | 0.84 | AGTR1 (1.00) | AGTR1AGTR2 | |
| SCHEMBL541 | 0.84 | AGTR1 (0.69) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL8565506 | 0.84 | AGTR2 (0.69) | AGTR1AGTR2 | |
| SCHEMBL4293944 | 0.83 | AGTR2 (0.71) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL9468476 | 0.83 | AGTR1 (0.98) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649424-B1 | DIOXCYCLOBUTENE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS | KNOLL AG (DE) | 1998-10-07 | — | — | EP | disclosed |
| US-5627191-A | Therapeutic agents | THE BOOTS COMPANY PLC (GB) | 1997-05-06 | — | — | US | disclosed |
| WO-1994001436-A1 | DIOXCYCLOBUTENE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS | THE BOOTS COMPANY PLC (GB) | 1994-01-20 | — | — | WO | disclosed |