Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4886483 | 0.87 | LMNA (0.50) | KMT2AMEN1POLBLMNAMAPK1 | |
| SCHEMBL1069525 | 0.85 | PTGS2 (0.43) | KMT2ALMNAMAPK1PPARAPPARG | |
| SCHEMBL28755926 | 0.83 | PTGS2 (0.51) | KMT2AMEN1POLBLMNAMAPK1 | |
| SCHEMBL8565844 | 0.82 | KMT2A (0.40) | KMT2AMEN1POLBLMNAMAPK1 | |
| SCHEMBL10334974 | 0.79 | MEN1 (0.43) | KMT2AMEN1POLBLMNAMAPK1 | |
| SCHEMBL11331364 | 0.78 | MEN1 (0.43) | KMT2AMEN1POLBLMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL11840084 | 0.78 | PPARA (0.41) | KMT2ALMNAMAPK1PPARAPPARG | |
| SCHEMBL11590724 | 0.77 | MEN1 (0.47) | KMT2AMEN1POLBLMNAMAPK1 | |
| SCHEMBL27667894 | 0.77 | KMT2A (0.45) | KMT2AMEN1POLBLMNASMN1; SMN2 | |
| SCHEMBL3863819 | 0.77 | KMT2A (0.45) | KMT2AMEN1POLBLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603001-B1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1998-08-26 | — | — | EP | disclosed |
| EP-0603001-A1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO COMPANY LIMITED (JP) | 1994-06-22 | — | — | EP | disclosed |