Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1901275 | 0.89 | KMT2A (0.46) | KMT2AMEN1POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL9890687 | 0.86 | SLC6A4 (0.55) | KMT2AMEN1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL8565449 | 0.82 | KMT2A (0.42) | KMT2AMEN1POLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL9890704 | 0.80 | ALDH1A1 (0.43) | KMT2AMEN1POLBALDH1A1HPGD | |
| SCHEMBL9890691 | 0.79 | KCNA5 (0.46) | KMT2AALDH1A1SLC6A3SLC6A4CTSA | |
| SCHEMBL9890700 | 0.78 | CHRM3 (0.40) | KMT2AMEN1ALDH1A1SLC6A3SLC6A4 | |
| SCHEMBL9890688 | 0.77 | HSP90AA1 (0.46) | KMT2AMEN1SMN1; SMN2SLC6A3NPC1 | |
| SCHEMBL9890686 | 0.77 | TUBB4A (0.44) | HPGDKDM4ESLC6A3SLC6A4HSD17B10 | |
| SCHEMBL9666407 | 0.76 | KMT2A (0.46) | KMT2AMEN1ALDH1A1L3MBTL1GAA | |
| SCHEMBL9666399 | 0.76 | KMT2A (0.46) | KMT2AMEN1ALDH1A1L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603001-B1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1998-08-26 | — | — | EP | disclosed |
| US-5459148-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0603001-A1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO COMPANY LIMITED (JP) | 1994-06-22 | — | — | EP | disclosed |