Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 10/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10619218 | 1.00 | DNM1 (0.53) | DNM1HTTHSP90AA1RAD52KMT2A | |
| Bromide SCHEMBL8561268 | 1.00 | DNM1 (0.53) | DNM1HTTHSP90AA1RAD52KMT2A | |
| Methacrylic Acid SCHEMBL9137895 | 0.82 | HTT (0.60) | DNM1HTTHSP90AA1RAD52KMT2A | |
| SCHEMBL18044444 | 0.82 | BBOX1 (0.57) | DNM1HTTHSP90AA1RAD52KMT2A | |
| SCHEMBL10794679 | 0.81 | GPR84 (0.58) | KMT2A | |
| SCHEMBL1119569 | 0.81 | GPR84 (0.58) | KMT2A | |
| SCHEMBL147810 | 0.81 | GPR84 (0.58) | KMT2A | |
| SCHEMBL3947983 | 0.81 | GPR84 (0.58) | KMT2A | |
| SCHEMBL153388 | 0.81 | GPR84 (0.58) | KMT2A | |
| SCHEMBL3435975 | 0.81 | GPR84 (0.58) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5725789-A | FOR FABRICS; POLYALKOXYLATED POLYURETHANE, FLUOROCHEMICAL ACRYLATE POLYMER | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1998-03-10 | — | — | US | disclosed |
| WO-1996030584-A1 | AQUEOUS OIL AND WATER REPELLENT COMPOSITIONS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1996-10-03 | — | — | WO | disclosed |