Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 9/20 | 0.80 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | TACR2 | P21452 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564833 | 0.91 | OPRM1 (0.83) | TACR1OPRM1CHRM2CHRM3 | |
| SCHEMBL8569082 | 0.90 | OPRM1 (0.79) | TACR1OPRM1CHRM2CHRM3LMNA | |
| SCHEMBL8568874 | 0.90 | OPRM1 (0.81) | TACR1OPRM1CHRM2CHRM3LMNA | |
| Ammonia Solution, Strong SCHEMBL8569084 | 0.89 | OPRM1 (0.80) | TACR1OPRM1CHRM2CHRM3LMNA | |
| SCHEMBL3650479 | 0.87 | TACR1 (0.66) | TACR1OPRM1LMNAGAAMAPT | |
| SCHEMBL8569779 | 0.87 | OPRM1 (0.77) | TACR1OPRM1CHRM2CHRM3TACR2 | |
| SCHEMBL8831751 | 0.87 | OPRM1 (0.74) | TACR1OPRM1CHRM2CHRM3LMNA | |
| SCHEMBL8570478 | 0.86 | OPRM1 (0.77) | TACR1OPRM1CHRM3 | |
| Phthalimide SCHEMBL8831756 | 0.86 | OPRM1 (0.73) | TACR1OPRM1CHRM2CHRM3LMNA | |
| SCHEMBL8566177 | 0.85 | OPRM1 (0.75) | TACR1OPRM1CHRM2CHRM3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708101-B1 | Piperidine derivatives, useful as neurokinin receptor antagonists | ADIR (FR) | 1998-12-09 | — | — | EP | claimed |
| US-5652246-A | NEUROKININ RECEPTOR ANTAGONISTS; NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-07-29 | — | — | US | claimed |
| EP-0708101-A1 | Novel piperidine derivatives, useful as neurokinin receptor antagonists | ADIR ET COMPAGNIE (FR) | 1996-04-24 | — | — | EP | claimed |
| EP-0708101-B1 | Piperidine derivatives, useful as neurokinin receptor antagonists | ADIR (FR) | 1998-12-09 | — | — | EP | disclosed |
| US-5652246-A | NEUROKININ RECEPTOR ANTAGONISTS; NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-07-29 | — | — | US | disclosed |
| EP-0708101-A1 | Novel piperidine derivatives, useful as neurokinin receptor antagonists | ADIR ET COMPAGNIE (FR) | 1996-04-24 | — | — | EP | disclosed |