Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.77 |
| ▸ | TACR1 | P25103 | 4/20 | 0.77 |
| ▸ | CHRM2 | P08172 | 9/20 | 0.60 |
| ▸ | CHRM3 | P20309 | 9/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | TACR2 | P21452 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8568874 | 0.91 | OPRM1 (0.81) | OPRM1TACR1CHRM2CHRM3MEN1 | |
| Ammonia Solution, Strong SCHEMBL8569084 | 0.91 | OPRM1 (0.80) | OPRM1TACR1CHRM2CHRM3MEN1 | |
| SCHEMBL8564833 | 0.89 | OPRM1 (0.83) | OPRM1TACR1CHRM2CHRM3ADRA1A | |
| SCHEMBL8569082 | 0.88 | OPRM1 (0.79) | OPRM1TACR1CHRM2CHRM3ADRA1A | |
| SCHEMBL8566177 | 0.87 | OPRM1 (0.75) | OPRM1TACR1CHRM2CHRM3OPRD1 | |
| SCHEMBL8565669 | 0.87 | TACR1 (0.80) | OPRM1TACR1CHRM2CHRM3TACR2 | |
| Phthalimide SCHEMBL8831756 | 0.85 | OPRM1 (0.73) | OPRM1TACR1CHRM2CHRM3MEN1 | |
| SCHEMBL8565932 | 0.85 | OPRM1 (0.70) | OPRM1TACR1CHRM2CHRM3ADRA1A | |
| SCHEMBL8831751 | 0.85 | OPRM1 (0.74) | OPRM1TACR1CHRM2CHRM3ADRA1A | |
| Ammonia Solution, Strong SCHEMBL8567391 | 0.85 | OPRM1 (0.74) | OPRM1TACR1CHRM2CHRM3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708101-B1 | Piperidine derivatives, useful as neurokinin receptor antagonists | ADIR (FR) | 1998-12-09 | — | — | EP | disclosed |
| US-5652246-A | NEUROKININ RECEPTOR ANTAGONISTS; NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-07-29 | — | — | US | disclosed |
| EP-0708101-A1 | Novel piperidine derivatives, useful as neurokinin receptor antagonists | ADIR ET COMPAGNIE (FR) | 1996-04-24 | — | — | EP | disclosed |