Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.81 |
| ▸ | TACR1 | P25103 | 4/20 | 0.81 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 9/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL8569084 | 0.99 | OPRM1 (0.80) | OPRM1TACR1CHRM2CHRM3CNR2 | |
| Phthalimide SCHEMBL8831756 | 0.94 | OPRM1 (0.73) | OPRM1TACR1CHRM2CHRM3CNR2 | |
| Ammonia Solution, Strong SCHEMBL8567391 | 0.93 | OPRM1 (0.74) | OPRM1TACR1CHRM2CHRM3CNR2 | |
| SCHEMBL8564833 | 0.92 | OPRM1 (0.83) | OPRM1TACR1CHRM2CHRM3 | |
| SCHEMBL8569082 | 0.91 | OPRM1 (0.79) | OPRM1TACR1CHRM2CHRM3CNR2 | |
| SCHEMBL8569779 | 0.91 | OPRM1 (0.77) | OPRM1TACR1CHRM2CHRM3MEN1 | |
| SCHEMBL8566177 | 0.90 | OPRM1 (0.75) | OPRM1TACR1CHRM2CHRM3CNR2 | |
| SCHEMBL8565669 | 0.90 | TACR1 (0.80) | OPRM1TACR1CHRM2CHRM3CNR2 | |
| Phthalimide SCHEMBL8831822 | 0.88 | OPRM1 (0.67) | OPRM1TACR1CHRM2CHRM3CNR2 | |
| SCHEMBL8831751 | 0.88 | OPRM1 (0.74) | OPRM1TACR1CHRM2CHRM3CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708101-B1 | Piperidine derivatives, useful as neurokinin receptor antagonists | ADIR (FR) | 1998-12-09 | — | — | EP | disclosed |
| US-5652246-A | NEUROKININ RECEPTOR ANTAGONISTS; NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-07-29 | — | — | US | disclosed |
| EP-0708101-A1 | Novel piperidine derivatives, useful as neurokinin receptor antagonists | ADIR ET COMPAGNIE (FR) | 1996-04-24 | — | — | EP | disclosed |