Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 6/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.46 |
| ▸ | PPARA | Q07869 | 3/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 4/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | KYNU | Q16719 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562043 | 0.94 | PPARA (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8565717 | 0.81 | TSHR (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6089700 | 0.80 | PPARA (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7822488 | 0.79 | CTSL (0.44) | PPARAKLK5CTSSACE | |
| SCHEMBL8893110 | 0.77 | PPARA (0.54) | PPARAPPARGCTSSSYKACE | |
| SCHEMBL8893121 | 0.77 | PPARA (0.54) | PPARAPPARGCTSSSYKACE | |
| SCHEMBL20364471 | 0.75 | KYNU (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8560370 | 0.74 | PPARA (0.47) | PPARAPPARGCTSSACE | |
| SCHEMBL15122799 | 0.74 | KYNU (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15122801 | 0.74 | KYNU (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811431-A | Spiro-substituted azacyclic derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 1998-09-22 | — | — | US | disclosed |