Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.51 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8352698 | 0.81 | L3MBTL1 (0.60) | SIGMAR1L3MBTL3L3MBTL1HRH3CYP1A2 | |
| SCHEMBL13958511 | 0.81 | HRH3 (0.70) | SIGMAR1L3MBTL3L3MBTL1HRH3ALDH1A1 | |
| SCHEMBL12281936 | 0.79 | SIGMAR1 (0.55) | SIGMAR1L3MBTL3L3MBTL1HRH3ALDH1A1 | |
| SCHEMBL8913567 | 0.79 | KCNJ1 (0.68) | SIGMAR1HRH3 | |
| SCHEMBL321095 | 0.78 | SIGMAR1 (0.60) | SIGMAR1L3MBTL3L3MBTL1HRH3ALDH1A1 | |
| SCHEMBL5023614 | 0.76 | HRH3 (0.65) | SIGMAR1HRH3ALDH1A1MAPTMEN1 | |
| SCHEMBL15651638 | 0.76 | SIGMAR1 (0.53) | SIGMAR1L3MBTL3L3MBTL1HRH3ALDH1A1 | |
| SCHEMBL5651768 | 0.76 | SIGMAR1 (0.64) | SIGMAR1L3MBTL3L3MBTL1HRH3ALDH1A1 | |
| SCHEMBL1877934 | 0.76 | HRH3 (0.68) | SIGMAR1L3MBTL3L3MBTL1HRH3ALDH1A1 | |
| SCHEMBL8564169 | 0.75 | KCNH2 (0.72) | SIGMAR1L3MBTL3L3MBTL1HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431943-B1 | Spiro(pyran)piperidine derivatives | MERCK & CO INC (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0431943-A2 | Nitrogen-containing spirocycles | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |