SCHEMBL8566290

SCHEMBL8566290

Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)NNS(C)(=O)=O

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EDNRA P25101 20/20 0.51
EDNRB P24530 19/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8628488 0.73 HPGDS (0.51) EDNRAEDNRB
SCHEMBL8566286 0.72 EDNRA (0.58) EDNRAEDNRB
SCHEMBL8717479 0.72 EDNRA (0.52) EDNRAEDNRB
SCHEMBL6639687 0.72 EDNRA (0.80) EDNRAEDNRB
SCHEMBL7143561 0.71 EDNRA (0.46) EDNRAEDNRB
SCHEMBL6641034 0.71 EDNRA (0.79) EDNRAEDNRB
SCHEMBL6957901 0.70 EDNRA (0.79) EDNRAEDNRB
SCHEMBL6640375 0.70 EDNRA (0.80) EDNRAEDNRB
SCHEMBL7506365 0.70 EDNRA (0.45) EDNRAEDNRB
SCHEMBL17689149 0.69 MAOB (0.42) EDNRAEDNRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5846990-A Substituted biphenyl isoxazole sulfonamides BRISTOL-MYERS SQUIBB CO. (US) 1998-12-08 US disclosed