Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 5/20 | 0.56 |
| ▸ | EDNRA | P25101 | 5/20 | 0.56 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.44 |
| ▸ | FEN1 | P39748 | 5/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6026444 | 0.88 | BRD4 (0.43) | EDNRBEDNRALTA4HALOX5APFEN1 | |
| SCHEMBL7868303 | 0.85 | EDNRB (0.56) | EDNRBEDNRALTA4HHPGDSFAAH | |
| SCHEMBL7408116 | 0.85 | BRD4 (0.41) | EDNRBEDNRALTA4HALOX5APFEN1 | |
| SCHEMBL7402494 | 0.80 | EDNRB (0.41) | EDNRBEDNRAALOX5APFEN1 | |
| SCHEMBL372585 | 0.80 | LTA4H (0.43) | EDNRBEDNRALTA4HHPGDSFAAH | |
| SCHEMBL5822874 | 0.79 | PTGS2 (0.54) | — | |
| SCHEMBL8350056 | 0.79 | CA1 (0.54) | ALOX5APFEN1 | |
| SCHEMBL18118210 | 0.78 | CA2 (0.54) | LTA4H | |
| SCHEMBL8717479 | 0.76 | EDNRA (0.52) | EDNRBEDNRA | |
| SCHEMBL8566286 | 0.76 | EDNRA (0.58) | EDNRBEDNRAALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1328523-A2 | METHODS FOR THE PREPARATION OF BIPHENYL ISOXAZOLE SULFONAMIDES | Bristol-Myers Squibb Company (US) | 2003-07-23 | — | — | EP | claimed |
| WO-2002032884-A2 | METHODS FOR THE PREPARATION OF BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-04-25 | — | — | WO | claimed |