Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.48 |
| ▸ | WNT3A | P56704 | 14/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.42 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.42 |
| ▸ | SNRK | Q9NRH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827115 | 0.85 | CYP1A2 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7278617 | 0.80 | GABRP (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3092847 | 0.80 | GABRP (0.62) | WNT3A | |
| SCHEMBL2022675 | 0.79 | ALDH1A1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Hydrochloric Acid SCHEMBL7493596 | 0.79 | GABRP (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8567027 | 0.79 | GABRP (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10528131 | 0.79 | EPHX2 (0.54) | — | |
| SCHEMBL10527578 | 0.77 | EPHX2 (0.56) | — | |
| SCHEMBL11077036 | 0.77 | GABRP (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29658465 | 0.77 | GABRP (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | claimed |