Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | RAB9A | P51151 | 10/20 | 0.77 |
| ▸ | NPC1 | O15118 | 9/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.72 |
| ▸ | POLB | P06746 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | KDR | P35968 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | XBP1 | P17861 | 1/20 | 0.60 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.60 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29432939 | 0.86 | RAB9A (0.78) | KDM4ERAB9ANPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL29432916 | 0.84 | RAB9A (1.00) | KDM4ERAB9ANPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL29432912 | 0.84 | RAB9A (1.00) | KDM4ERAB9ANPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL879571 | 0.83 | KDM4E (0.70) | KDM4ERAB9ANPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL27866684 | 0.82 | NPC1 (0.80) | KDM4ERAB9ANPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL651159 | 0.81 | KDR (0.74) | KDM4ERAB9ANPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL8562464 | 0.80 | RAB9A (0.72) | KDM4ERAB9ANPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL8568774 | 0.80 | KDM4E (0.67) | KDM4ERAB9ANPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL14461305 | 0.80 | HDAC1 (0.72) | KDM4ERAB9ANPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL3994400 | 0.80 | NPSR1 (0.71) | KDM4ERAB9ANPC1SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |